prediction of lung cells oncogenic transformation for induced radon progeny alpha particles using sugarscape cellular automata

نویسندگان

samaneh baradaran a. dept. of medical radiation engineering, amirkabir university of technology, tehran, iran b. radiation application school, nuclear sciences and technology research institute, tehran, iran

niaz maleknasr faculty of engineering, science and research branch, islamic azad university, tehran, iran

saeed setayeshi dept. of medical radiation engineering, amirkabir university of technology, tehran, iran

mohammad esmail akbari cancer research center, shahid beheshti university of medical sciences, tehran, iran

چکیده

background: alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. the biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interactions. the cellular and molecular mechanisms for radon-induced carcinogenesis have not been clear yet. methods: various biological models, including cultured cells and animals, have been found useful for studying the carcinogenesis effects of radon progeny alpha particles. in this paper, sugars cape cellular automata have been presented for computational study of complex biological effect of radon progeny alpha particles in lung bronchial airways. the model has included mechanism of dna damage, which has been induced alpha particles hits, and then formation of transformation in the lung cells. biomarkers were an objective measure or evaluation of normal or abnormal biological processes. in the model, the metabolism rate of infected cell has been induced alpha particles traversals, as a biomarker, has been followed to reach oncogenic transformation. results: the model results have successfully validated in comparison with “in vitro oncogenic transformation data” for c3h 10t1/2 cells. this model has provided an opportunity to study the cellular and molecular changes, at the various stages in radiation carcinogenesis, involving human cells. conclusion: it has become well known that simulation could be used to investigate complex biomedical systems, in situations where traditional methodologies were difficult or too costly to employ.

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Prediction of Lung Cells Oncogenic Transformation for Induced Radon Progeny Alpha Particles Using Sugarscape Cellular Automata

BACKGROUND Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interactions...

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Alpha particle irradiation from radon progeny is one of the major natural source of effective dose for public population. Oncogenic transformation is a biological effectivness of radon progeny alpha particle hits. Various biological models including cultured cells and animals have been found useful for studing the carcinogenesis effects of radon progeny alpha particles. In this paper, sugarscap...

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Biological effects of radiation are due to energy deposition arising from the alpha particles hits with cell nuclei. A simulation has been done to calculate the flux density of Radon progeny alpha particles induced from uniform inner surface source distributed in lung cylindrical airway using Monte Carlo method. Number of hits, transformation frequency and dose has been calculated using obtaine...

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عنوان ژورنال:
iranian journal of cancer prevention

جلد ۷، شماره ۱، صفحات ۰-۰

کلمات کلیدی
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